James O’Keefe, MD, FACC


James H O’Keefe MD, FACC, is a Board Certified Cardiologist and Director of both the Charles & Barbara Duboc Cardio Health & Wellness Center and the Preventive Cardiology service at Saint Luke’s Mid America Heart Institute. He is also Professor of Medicine at the University of Missouri-Kansas City. His postgraduate training included a cardiology fellowship at Mayo Clinic in Rochester, Minnesota.

Dr O’Keefe is board-certified in Cardiology, Internal Medicine, Nuclear Cardiology, and Cardiac CT Imaging. He is consistently ranked among the ‘Top Doctor’ lists regionally and nationally as one of America’s Top Rated Physicians in Cardiology.  He has also been named as one of USA Today’s Most Influential Doctors.


Dr O’Keefe has contributed more than 350 articles to medical literature and has authored best-selling cardiovascular books for health professionals including: The Complete Guide to ECGs (which is used for Cardiology Board Certification), Dyslipidemia Essentials, and Diabetes Essentials. He lectures extensively on the role of therapeutic lifestyle changes and drug therapy in cardiovascular risk reduction.

Dr O’Keefe has participated in TEDx talks in conjunction with the University of Missouri-Kansas City regarding excessive exercise (https://youtu.be/Y6U728AZnV0) and TEDx Tallaght on Homosexuality: It’s about Survival – not Sex (https://youtu.be/4Khn_z9FPmU).  In June 2018, Dr O’Keefe presented a TEDx talk in Manchester, England, is focusing on “Play With Your Friends – Save Your Life.”  This video should be available August 2018.

Dr O’Keefe has coauthored, with his wife Joan, the best-selling consumer health books, The Forever Young Diet and Lifestyle and Let Me Tell You a Story. He is actively involved in both patient care and research.